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MOTS-c vial, Diluent
Metabolic & GLP-1

Buy MOTS-c in the UK

MOTS-c is a 16-residue peptide encoded in mitochondrial DNA rather than the nucleus, available as a 5mg or 10mg vial. Research use only.

from £15.992 options

  • In UK stock Sent from Britain
  • Leaves the same day When ordered before 2pm
  • Tracked shipping No charge over £75
  • Certificate of analysis Available on request

Prices for MOTS-c start at £15.99 for the 5mg vial, and all of it is already in British stock at diluents.co.uk rather than sourced to order. There are 2 strengths to choose from (5mg, 10mg), offered as vial. Order on a weekday before 2pm and the parcel leaves that day, tracked, in a box that gives no clue to its contents.

Because the parcel never leaves the country, nothing has to clear customs, no import charge falls due and nothing is held at a border. Each batch tests at ≥99% by HPLC, and a certificate of analysis for the stock you receive is available on request.

Tracked delivery costs £4.95, or nothing above £75. The ordering steps, one by one.

Every MOTS-c size and format

2 to choose from
MOTS-c 5mg vial MOTS-c 5mg Vial · £3.20/mg
£15.99
MOTS-c 10mg vial MOTS-c 10mg Vial · £2.30/mg
£22.99

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What is MOTS-c?

Unusually, the mitochondrial 12S rRNA is where this sixteen-residue peptide is coded, in a short open reading frame, so its instructions sit in the mitochondria. That makes MOTS-c one of the mitochondrial-derived peptides.

Specification

Residues16
Coded inAn open reading frame in mitochondrial 12S rRNA
Molecular formulaC101H152N28O22S2
Molecular weight2,174.6
CAS1627580-64-6
Purity≥99% by HPLC
Vial strengths5mg, 10mg
Certificate of analysisAvailable on request

Which studies have looked at MOTS-c?

All of the published work on MOTS-c is pre-clinical, and no paper listed below is a trial in humans. Grouped by study model, here is what each paper examined:

Literature reviews

  • MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism, Review (PMID 27216708)

In-vitro and animal studies

  • The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance, Mouse and in-vitro (PMID 25738959)

Every entry names what a study examined. No entry reports an effect in a person, and nowhere does the site give instructions on how to use anything.

Buying MOTS-c in the UK: where and how

How does ordering work?

Choose a strength, add it to the basket and go through checkout; no account is needed. An order confirmation comes through at once, and since the site never takes a card, the payment details arrive separately by email.

What difference does UK stock make?

Your MOTS-c is sent from a warehouse in Britain, so it skips customs, attracts no import charge and loses no days travelling from overseas. A courier collects it the same afternoon if the order is in before 2pm on a working day; the parcel then travels tracked in a plain outer box.

What do you receive?

Purity≥99%, measured by HPLC
LabellingCompound name, strength, format, purity and a research-use statement
Certificate of analysisAvailable on request for the stock you receive
DeliveryUK addresses only, tracked. £4.95, or free over £75
ReturnsWithin 14 days for sealed, unopened items, see the terms

MOTS-c reconstitution

What ships is a dry, freeze-dried cake, and bacteriostatic water is what turns it into a solution. The volume you choose sets how strong that solution ends up. Water only spreads the contents out; it never adds to or takes from the milligrams sealed in the vial.

2.50 mg/mlConcentration
0.100 mlHolds 0.25mg
10.0 unitsOn a U-100 syringe
25 mcgPer unit of that syringe

The figures above are volumes and concentrations of a solution; none of them is a dose, and no guidance on dosing, protocols or administration is given on this site.

The figures open on the 5mg vial with 2ml added, and they update as soon as either control changes. For the syringe-scale conversion, a comparison of the waters and the keeping time of a mixed vial, use the full reconstitution calculator.

mg/ml reached for each vial size and volume of water
Vial+ 1ml+ 2ml+ 3ml+ 5ml
5mg 5 mg/ml2.5 mg/ml1.67 mg/ml1 mg/ml
10mg 10 mg/ml5 mg/ml3.33 mg/ml2 mg/ml

As a worked case, the 5mg vial with 2ml of bacteriostatic water comes to 2.5 mg/ml, which is simply the label milligrams divided by the millilitres added. Every number in the table is the concentration of a solution, never a dose. Dosage, protocol and administration guidance appear nowhere on this site.

Asked about mixing MOTS-c

How long does MOTS-c last after reconstitution?

Once the vial is at room temperature and the stopper has been swabbed, the bacteriostatic water goes in along the glass wall, away from the powder. Keep rolling until the solution is clear, and do not shake. The volume chosen fixes the concentration; for the 5mg vial, 1ml gives 5 mg/ml, 2ml gives 2.5 mg/ml, 3ml gives 1.67 mg/ml, 5ml gives 1 mg/ml.

How much bac water for 10mg MOTS-c?

Spread through the four usual volumes, 10mg works out like this: 1ml gives 10 mg/ml, 2ml gives 5 mg/ml, 3ml gives 3.33 mg/ml, 5ml gives 2 mg/ml. That strength is one we sell, with a row in the table above and an entry in the picker.

What care does the vial need?

  • A chilled vial should warm to room temperature first.
  • Before every entry through the stopper, clean it with an alcohol swab.
  • Let the water run down the inside wall of the glass; never squirt it onto the cake.
  • Roll, never shake: foam means protein has been damaged, and rolling between the fingers avoids it.
  • Expect a few minutes before it dissolves fully; a correctly mixed vial ends up clear.

MOTS-c storage

Vial, still sealedKeep it dark, dry and cool; the freezer suits long-term storage best.
After mixingRefrigerate it upright and shaded. A mixed solution should never be frozen.

What is its shelf life?

Typical keeping times for lyophilised peptides in general
ConditionTypical life
Unopened, in a −20 °C freezerYears. No other condition preserves a lyophilised peptide as well
Unopened, in a fridge at 2–8 °CMonths
Unopened, at room temperatureWeeks. It copes with the time in transit but should not be kept like this
Mixed, in the fridgeWeeks rather than months. With bacteriostatic water added, the usual working figure is four weeks, and making that possible is the job of its preservative
Mixed, then frozenNot recommended. Peptides are torn by ice crystals, and each freeze–thaw cycle compounds the damage

These are the standard figures for lyophilised peptides in general; no stability study on a single batch produced them. Time is gained by keeping it cold and dry, and lost to damp, warmth, light and rough handling. A certificate of analysis is available on request.

Here it is supplied strictly as an unlicensed compound for laboratory research use only. No UK marketing authorisation covers MOTS-c and it is not a licensed medicine, nor is it intended for human or veterinary use, or for food.

Compounds of this kind are not controlled drugs, and they can lawfully be sold as laboratory material; it is selling or marketing them for use by people that the law does not allow. That boundary is why this site carries no dose, protocol, route, frequency or medical claim, and why an emailed request for one is declined as well.

Some molecules in this range are also present in a licensed medicine marketed under a brand name. Its authorisation covers only the finished product for which it was granted, not the molecule in any other setting. Read the full terms.

Research use only. Diluent is not a pharmacy, and none of its compounds is a licensed medicine: everything is sold for laboratory research, with no dosage, protocol or administration guidance given. Not intended for human or veterinary use, or for use in food.

Questions about MOTS-c

What is a mitochondrial-derived peptide?

A peptide encoded by mitochondrial DNA, not by the nuclear genome. In the case of MOTS-c, the coding sequence lies within the mitochondrial 12S rRNA.

Which sizes can I order?

A 5mg or a 10mg vial.

What is MOTS-c peptide?

The MOTS-c sold here is an unlicensed research compound, supplied for laboratory research only, and HPLC assay puts it at ≥99% purity. Further down this page you will find the full specification alongside the published studies.

Where can I buy MOTS-c peptide?

In the UK, diluents.co.uk supplies MOTS-c in 2 strengths from 5mg up to 10mg, as vials, priced from £15.99. With the stock already in Britain, there is no clearance to wait on, no import charge and no risk of a border stop. The per-milligram cost falls as the size rises, from £3.20/mg on the smallest vial to £2.30/mg at the best rate, and each size lists its own figure. Because it is supplied as freeze-dried powder, the concentration is whatever you choose when it is mixed. Orders placed before 2pm on a weekday go out the same day, tracked and in plain packaging. Each batch goes through third-party lab testing and returns an HPLC result of ≥99%; the certificate covering yours is available on request, and for the steps, see how to order.

How much does MOTS-c cost?

Prices begin at £15.99 with the 5mg, £3.20 a milligram. Each of the 2 options carries a separate price and a separate per-milligram rate. Delivery costs £4.95, and above £75 there is no charge at all.

How long does MOTS-c last?

Unopened and dry, it lasts for years in a freezer at −20 °C, for months refrigerated at 2–8 °C and for weeks at room temperature; the colder and drier the conditions, the longer it keeps. Once mixed with bacteriostatic water it belongs upright in the fridge, where four weeks is the usual working figure. A mixed vial must never be frozen, because ice crystals rip peptides apart and every freeze–thaw cycle repeats the damage.

Is MOTS-c banned by wada?

Our MOTS-c is supplied strictly for laboratory research, as an unlicensed research compound and for no other purpose. No UK marketing authorisation covers the product we sell, so it is not a licensed medicine; it is also not for human or veterinary use. Nor are we a pharmacy.

Can I see a certificate for your MOTS-c, and what purity is it?

Yes. HPLC puts it at ≥99%, and on request we send the certificate of analysis that matches the material in your order. To check where current stock stands before you place an order, just ask and we will tell you.

References

  1. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism, 2015;21(3):443-454. PMID 25738959
  2. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. PMID 27216708

Follow any link to read the original paper in full.